Metabolic labeling of cardiomyocyte‐derived small extracellular‐vesicle (sEV) miRNAs identifies miR‐208a in cardiac regulation of lung gene expression

Metabolic labeling of cardiomyocyte‐derived small extracellular‐vesicle (sEV) miRNAs identifies miR‐208a in cardiac regulation of lung gene expression

Abstract Toxoplasma gondii uracil phosphoribosyltransferase (UPRT) converts 4‐thiouracil (4TUc) into 4‐thiouridine (4TUd), which is incorporated into nascent RNAs and can be biotinylated, then labelled with streptavidin conjugates or isolated via streptavidin‐affinity methods. Here, we generated mic...

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Bibliographic Details
Main Authors: Chaoshan Han, Junjie Yang, Eric Zhang, Ying Jiang, Aijun Qiao, Yipeng Du, Qinkun Zhang, Junqing An, Jiacheng Sun, Meimei Wang, Thanh Nguyen, Hind Lal, Prasanna Krishnamurthy, Jianyi Zhang, Gangjian Qin
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Journal of Extracellular Vesicles
Subjects:
endothelial cells
extracellular vesicles
lung
miR‐208a
myocardial infarction
UPRT
Online Access:https://doi.org/10.1002/jev2.12246

Internet

https://doi.org/10.1002/jev2.12246

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