An OX40L mRNA vaccine inhibits the growth of hepatocellular carcinoma

An OX40L mRNA vaccine inhibits the growth of hepatocellular carcinoma

mRNA cancer vaccines show therapeutic potential for malignant tumors, including hepatocellular carcinoma (HCC). We optimized and synthesized stable mRNA encoding costimulator Oxford 40 ligand (OX40L). For systemic delivery, OX40L mRNAs were loaded into lipid nanoparticles (LNPs). The expression and...

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Bibliographic Details
Main Authors: Zhuoya Deng, Hao Yang, Yuying Tian, Zherui Liu, Fang Sun, Penghui Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
OX40L
mRNA cancer vaccine
hepatocellular carcinoma
immunotherapy
lipid nanoparticle
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.975408/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.975408/full

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