Lactobacillus acidophilus and propionate attenuate Sjögren’s syndrome by modulating the STIM1-STING signaling pathway
Abstract Background Sjögren’s syndrome (SS) is an autoimmune disease characterized by inflammation of the exocrine gland. An imbalance of gut microbiota has been linked to SS. However, the molecular mechanism is unclear. We investigated the effects of Lactobacillus acidophilus (L. acidophilus) and p...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01141-0 |
| _version_ | 1797801347058237440 |
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| author | Jin Seok Woo Sun-Hee Hwang SeungCheon Yang Kun Hee Lee Yeon Su Lee Jeong Won Choi Jin-Sil Park JooYeon Jhun Sung-Hwan Park Mi-La Cho |
| author_facet | Jin Seok Woo Sun-Hee Hwang SeungCheon Yang Kun Hee Lee Yeon Su Lee Jeong Won Choi Jin-Sil Park JooYeon Jhun Sung-Hwan Park Mi-La Cho |
| author_sort | Jin Seok Woo |
| collection | DOAJ |
| description | Abstract Background Sjögren’s syndrome (SS) is an autoimmune disease characterized by inflammation of the exocrine gland. An imbalance of gut microbiota has been linked to SS. However, the molecular mechanism is unclear. We investigated the effects of Lactobacillus acidophilus (L. acidophilus) and propionate on the development and progression of SS in mouse model. Methods We compared the gut microbiomes of young and old mice. We administered L. acidophilus and propionate up to 24 weeks. The saliva flow rate and the histopathology of the salivary glands were investigated, and the effects of propionate on the STIM1-STING signaling pathway were evaluated in vitro. Results Lactobacillaceae and Lactobacillus were decreased in aged mice. SS symptoms were ameliorated by L. acidophilus. The abundance of propionate-producing bacterial was increased by L. acidophilus. Propionate ameliorated the development and progression of SS by inhibiting the STIM1-STING signaling pathway. Conclusions The findings suggest that Lactobacillus acidophilus and propionate have therapeutic potential for SS. Video Abstract |
| first_indexed | 2024-03-13T04:49:05Z |
| format | Article |
| id | doaj.art-fe462b290db14f55be88653c72b5de35 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-13T04:49:05Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-fe462b290db14f55be88653c72b5de352023-06-18T11:20:31ZengBMCCell Communication and Signaling1478-811X2023-06-0121111210.1186/s12964-023-01141-0Lactobacillus acidophilus and propionate attenuate Sjögren’s syndrome by modulating the STIM1-STING signaling pathwayJin Seok Woo0Sun-Hee Hwang1SeungCheon Yang2Kun Hee Lee3Yeon Su Lee4Jeong Won Choi5Jin-Sil Park6JooYeon Jhun7Sung-Hwan Park8Mi-La Cho9Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of KoreaRheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of KoreaRheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of KoreaRheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of KoreaRheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of KoreaRheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of KoreaRheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of KoreaRheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of KoreaRheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of KoreaRheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of KoreaAbstract Background Sjögren’s syndrome (SS) is an autoimmune disease characterized by inflammation of the exocrine gland. An imbalance of gut microbiota has been linked to SS. However, the molecular mechanism is unclear. We investigated the effects of Lactobacillus acidophilus (L. acidophilus) and propionate on the development and progression of SS in mouse model. Methods We compared the gut microbiomes of young and old mice. We administered L. acidophilus and propionate up to 24 weeks. The saliva flow rate and the histopathology of the salivary glands were investigated, and the effects of propionate on the STIM1-STING signaling pathway were evaluated in vitro. Results Lactobacillaceae and Lactobacillus were decreased in aged mice. SS symptoms were ameliorated by L. acidophilus. The abundance of propionate-producing bacterial was increased by L. acidophilus. Propionate ameliorated the development and progression of SS by inhibiting the STIM1-STING signaling pathway. Conclusions The findings suggest that Lactobacillus acidophilus and propionate have therapeutic potential for SS. Video Abstracthttps://doi.org/10.1186/s12964-023-01141-0Sjögren’s syndromeLactobacillus acidophilusPropionateStromal interaction moleculae 1 (STIM1)Stimulation of interferon genes (STING) |
| spellingShingle | Jin Seok Woo Sun-Hee Hwang SeungCheon Yang Kun Hee Lee Yeon Su Lee Jeong Won Choi Jin-Sil Park JooYeon Jhun Sung-Hwan Park Mi-La Cho Lactobacillus acidophilus and propionate attenuate Sjögren’s syndrome by modulating the STIM1-STING signaling pathway Cell Communication and Signaling Sjögren’s syndrome Lactobacillus acidophilus Propionate Stromal interaction moleculae 1 (STIM1) Stimulation of interferon genes (STING) |
| title | Lactobacillus acidophilus and propionate attenuate Sjögren’s syndrome by modulating the STIM1-STING signaling pathway |
| title_full | Lactobacillus acidophilus and propionate attenuate Sjögren’s syndrome by modulating the STIM1-STING signaling pathway |
| title_fullStr | Lactobacillus acidophilus and propionate attenuate Sjögren’s syndrome by modulating the STIM1-STING signaling pathway |
| title_full_unstemmed | Lactobacillus acidophilus and propionate attenuate Sjögren’s syndrome by modulating the STIM1-STING signaling pathway |
| title_short | Lactobacillus acidophilus and propionate attenuate Sjögren’s syndrome by modulating the STIM1-STING signaling pathway |
| title_sort | lactobacillus acidophilus and propionate attenuate sjogren s syndrome by modulating the stim1 sting signaling pathway |
| topic | Sjögren’s syndrome Lactobacillus acidophilus Propionate Stromal interaction moleculae 1 (STIM1) Stimulation of interferon genes (STING) |
| url | https://doi.org/10.1186/s12964-023-01141-0 |
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