FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes

FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes

Abstract Fibroblast growth factor (FGF) 21, a hormone that increases insulin sensitivity, has shown promise as a therapeutic agent to improve metabolic dysregulation. Here we report that FGF21 directly targets cardiac myocytes by binding β-klotho and FGF receptor (FGFR) 4. In combination with high g...

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Bibliographic Details
Main Authors: Christopher Yanucil, Dominik Kentrup, Xueyi Li, Alexander Grabner, Karla Schramm, Eliana C. Martinez, Jinliang Li, Isaac Campos, Brian Czaya, Kylie Heitman, David Westbrook, Adam R. Wende, Alexis Sloan, Johanna M. Roche, Alessia Fornoni, Michael S. Kapiloff, Christian Faul
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-11033-x

Internet

https://doi.org/10.1038/s41598-022-11033-x

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