Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP
How archaeal viruses perturb host transcription machinery is poorly understood. Here, the authors provide evidence that the archaeo-viral transcription factor ORF145/RIP targets host RNA polymerase, repressing its activity.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13595 |
| _version_ | 1818834952990490624 |
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| author | Carol Sheppard Fabian Blombach Adam Belsom Sarah Schulz Tina Daviter Katherine Smollett Emilie Mahieu Susanne Erdmann Philip Tinnefeld Roger Garrett Dina Grohmann Juri Rappsilber Finn Werner |
| author_facet | Carol Sheppard Fabian Blombach Adam Belsom Sarah Schulz Tina Daviter Katherine Smollett Emilie Mahieu Susanne Erdmann Philip Tinnefeld Roger Garrett Dina Grohmann Juri Rappsilber Finn Werner |
| author_sort | Carol Sheppard |
| collection | DOAJ |
| description | How archaeal viruses perturb host transcription machinery is poorly understood. Here, the authors provide evidence that the archaeo-viral transcription factor ORF145/RIP targets host RNA polymerase, repressing its activity. |
| first_indexed | 2024-12-19T02:43:00Z |
| format | Article |
| id | doaj.art-fe48d2500b7346f9935066ca430c0d80 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T02:43:00Z |
| publishDate | 2016-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fe48d2500b7346f9935066ca430c0d802022-12-21T20:39:05ZengNature PortfolioNature Communications2041-17232016-11-017111310.1038/ncomms13595Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIPCarol Sheppard0Fabian Blombach1Adam Belsom2Sarah Schulz3Tina Daviter4Katherine Smollett5Emilie Mahieu6Susanne Erdmann7Philip Tinnefeld8Roger Garrett9Dina Grohmann10Juri Rappsilber11Finn Werner12Division of Biosciences, Institute of Structural and Molecular Biology, University College LondonDivision of Biosciences, Institute of Structural and Molecular Biology, University College LondonWellcome Trust Centre for Cell Biology, University of EdinburghPhysikalische und Theoretische Chemie—NanoBioSciences, Technische Universität BraunschweigDivision of Biosciences, Institute of Structural and Molecular Biology, University College LondonDivision of Biosciences, Institute of Structural and Molecular Biology, University College LondonDivision of Biosciences, Institute of Structural and Molecular Biology, University College LondonDepartment of Biology, University of CopenhagenPhysikalische und Theoretische Chemie—NanoBioSciences, Technische Universität BraunschweigDepartment of Biology, University of CopenhagenPhysikalische und Theoretische Chemie—NanoBioSciences, Technische Universität BraunschweigWellcome Trust Centre for Cell Biology, University of EdinburghDivision of Biosciences, Institute of Structural and Molecular Biology, University College LondonHow archaeal viruses perturb host transcription machinery is poorly understood. Here, the authors provide evidence that the archaeo-viral transcription factor ORF145/RIP targets host RNA polymerase, repressing its activity.https://doi.org/10.1038/ncomms13595 |
| spellingShingle | Carol Sheppard Fabian Blombach Adam Belsom Sarah Schulz Tina Daviter Katherine Smollett Emilie Mahieu Susanne Erdmann Philip Tinnefeld Roger Garrett Dina Grohmann Juri Rappsilber Finn Werner Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP Nature Communications |
| title | Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP |
| title_full | Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP |
| title_fullStr | Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP |
| title_full_unstemmed | Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP |
| title_short | Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP |
| title_sort | repression of rna polymerase by the archaeo viral regulator orf145 rip |
| url | https://doi.org/10.1038/ncomms13595 |
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