Targeted Therapy of Uveal Melanoma: Recent Failures and New Perspectives

Targeted Therapy of Uveal Melanoma: Recent Failures and New Perspectives

Among Uveal Melanoma (UM) driver mutations, those involving <i>GNAQ</i> or <i>GNA11</i> genes are the most frequent, while a minor fraction of tumors bears mutations in the <i>PLCB4</i> or <i>CYSLTR2</i> genes. Direct inhibition of constitutively activ...

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Bibliographic Details
Main Authors: Michela Croce, Silvano Ferrini, Ulrich Pfeffer, Rosaria Gangemi
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
uveal melanoma
driver mutations
signaling pathways
targeted therapies
Online Access:https://www.mdpi.com/2072-6694/11/6/846

Internet

https://www.mdpi.com/2072-6694/11/6/846

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