Effect of arthritic synovial fluids on the expression of immunomodulatory factors by mesenchymal stem cells: an explorative in-vitro study

Background: In diseased joints, the catabolic environment results in progressive joint damage. Mesenchymal stem cells (MSCs) can have immunomodulatory effect by secreting anti-inflammatory factors. To exert these effects, MSCs need to be triggered by pro-inflammatory cytokines. To explore the potent...

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Bibliographic Details
Main Authors: Maarten J.C. Leijs, Gerben M. Van Buul, Erik eLubberts, Pieter K. Bos, Jan A.N. Verhaar, Martin J. Hoogduijn, Gerjo J.V.M. van Osch
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00231/full