Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation

Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation

Abstract Mutations in the RMRP-gene, encoding the lncRNA component of the RNase MRP complex, are the origin of cartilage-hair hypoplasia. Cartilage-hair hypoplasia is associated with severe dwarfism caused by impaired skeletal development. However, it is not clear why mutations in RMRP RNA lead to s...

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Bibliographic Details
Main Authors: Mandy M. F. Steinbusch, Marjolein M. J. Caron, Don A. M. Surtel, Franziska Friedrich, Ekkehart Lausch, Ger J. M. Pruijn, Wouter Verhesen, Blanche L. M. Schroen, Lodewijk W. van Rhijn, Bernhard Zabel, Tim J. M. Welting
Format: Article
Language:English
Published: Nature Portfolio 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-06809-5

Internet

https://doi.org/10.1038/s41598-017-06809-5

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