Small-molecule screening of ribonuclease L binders for RNA degradation

Small-molecule screening of ribonuclease L binders for RNA degradation

Small molecules targeting the ubiquitous latent ribonuclease (RNase L), which has limited sequence specificity toward single-stranded RNA substrates, hold great potential to be developed as broad-spectrum antiviral drugs by modulating the RNase L-mediated innate immune responses. The recent developm...

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Bibliographic Details
Main Authors: Lydia Borgelt, Neele Haacke, Philipp Lampe, Xiaqiu Qiu, Raphael Gasper, Damian Schiller, Jimin Hwang, Sonja Sievers, Peng Wu
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Small molecules
Binders
Innate immune response
Ribonuclease
RNA degradation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222009787

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http://www.sciencedirect.com/science/article/pii/S0753332222009787

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