A novel mouse model of anterior segment dysgenesis (ASD): conditional deletion of Tsc1 disrupts ciliary body and iris development

A novel mouse model of anterior segment dysgenesis (ASD): conditional deletion of Tsc1 disrupts ciliary body and iris development

Development of the cornea, lens, ciliary body and iris within the anterior segment of the eye involves coordinated interaction between cells originating from the ciliary margin of the optic cup, the overlying periocular mesenchyme and the lens epithelium. Anterior segment dysgenesis (ASD) encompasse...

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Bibliographic Details
Main Authors: Anna-Carin Hägglund, Iwan Jones, Leif Carlsson
Format: Article
Language:English
Published: The Company of Biologists 2017-03-01
Series:Disease Models & Mechanisms
Subjects:
Tsc1
mTORC1
Pax6
Ciliary body
Iris
Anterior segment dysgenesis
Online Access:http://dmm.biologists.org/content/10/3/245

Internet

http://dmm.biologists.org/content/10/3/245

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