Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline

Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline

Abstract Background Fatty acids play prominent roles in brain function as they participate in structural, metabolic and signaling processes. The homeostasis of fatty acids and related pathways is known to be impaired in cognitive decline and dementia, but the relationship between these metabolic dis...

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Main Authors: Raúl González-Domínguez, Pol Castellano-Escuder, Sophie Lefèvre-Arbogast, Dorrain Y. Low, Andrea Du Preez, Silvie R. Ruigrok, Hyunah Lee, Catherine Helmer, Mercè Pallàs, Mireia Urpi-Sarda, Alex Sánchez-Pla, Aniko Korosi, Paul J. Lucassen, Ludwig Aigner, Claudine Manach, Sandrine Thuret, Cécilia Samieri, Cristina Andres-Lacueva
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Cognitive decline
Fatty acids
Apolipoprotein E
Sex
Acyl-carnitines
Metabolomics
Online Access:https://doi.org/10.1186/s13195-021-00948-8

Internet

https://doi.org/10.1186/s13195-021-00948-8

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