An intranasal vaccine comprising SARS-CoV-2 spike receptor-binding domain protein entrapped in mannose-conjugated chitosan nanoparticle provides protection in hamsters

An intranasal vaccine comprising SARS-CoV-2 spike receptor-binding domain protein entrapped in mannose-conjugated chitosan nanoparticle provides protection in hamsters

Abstract We developed a novel intranasal SARS-CoV-2 subunit vaccine called NARUVAX-C19/Nano based on the spike protein receptor-binding domain (RBD) entrapped in mannose-conjugated chitosan nanoparticles (NP). A toll-like receptor 9 agonist, CpG55.2, was also added as an adjuvant to see if this woul...

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Bibliographic Details
Main Authors: Kairat Tabynov, Maxim Solomadin, Nurkeldi Turebekov, Meruert Babayeva, Gleb Fomin, Ganesh Yadagiri, Sankar Renu, Toktassyn Yerubayev, Nikolai Petrovsky, Gourapura J. Renukaradhya, Kaissar Tabynov
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-39402-0

Internet

https://doi.org/10.1038/s41598-023-39402-0

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