Loss of <i>swiss cheese</i> in Neurons Contributes to Neurodegeneration with Mitochondria Abnormalities, Reactive Oxygen Species Acceleration and Accumulation of Lipid Droplets in <i>Drosophila</i> Brain

Loss of <i>swiss cheese</i> in Neurons Contributes to Neurodegeneration with Mitochondria Abnormalities, Reactive Oxygen Species Acceleration and Accumulation of Lipid Droplets in <i>Drosophila</i> Brain

Various neurodegenerative disorders are associated with human NTE/PNPLA6 dysfunction. Mechanisms of neuropathogenesis in these diseases are far from clearly elucidated. Hereditary spastic paraplegia belongs to a type of neurodegeneration associated with NTE/PNLPLA6 and is implicated in neuron death....

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Bibliographic Details
Main Authors: Pavel A. Melentev, Elena V. Ryabova, Nina V. Surina, Darya R. Zhmujdina, Artem E. Komissarov, Ekaterina A. Ivanova, Natalia P. Boltneva, Galina F. Makhaeva, Mariana I. Sliusarenko, Andriy S. Yatsenko, Iryna I. Mohylyak, Nataliya P. Matiytsiv, Halyna R. Shcherbata, Svetlana V. Sarantseva
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
hereditary spastic paraplegia
<i>swiss cheese</i>
<i>NTE</i>
<i>PNPLA6</i>
<i>Drosophila melanogaster</i>
lipid droplets
Online Access:https://www.mdpi.com/1422-0067/22/15/8275

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https://www.mdpi.com/1422-0067/22/15/8275

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