CD73 Promotes Chronic Lymphocytic Leukemia

CD73 Promotes Chronic Lymphocytic Leukemia

The ecto-nucleotidase CD73 is an important immune checkpoint in tumor immunity that cooperates with CD39 to hydrolyze pro-inflammatory extracellular ATP into immunosuppressive adenosine. While the role of CD73 in immune evasion of solid cancers is well established, its role in leukemia remains uncle...

Full description

Bibliographic Details
Main Authors: David Allard, Pavel Chrobak, Yacine Bareche, Bertrand Allard, Priscilla Tessier, Marjorie A. Bergeron, Nathalie A. Johnson, John Stagg
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
CD73
adenosine
chronic lymphocytic leukemia
PD-L1
Online Access:https://www.mdpi.com/2072-6694/14/13/3130

Internet

https://www.mdpi.com/2072-6694/14/13/3130

Similar Items