Repressing HIF-1α-induced HDAC9 contributes to the synergistic effect of venetoclax and MENIN inhibitor in KMT2Ar AML

Repressing HIF-1α-induced HDAC9 contributes to the synergistic effect of venetoclax and MENIN inhibitor in KMT2Ar AML

Abstract KMT2A-rearranged acute myeloid leukemia (KMT2Ar-AML) is an aggressive subtype of AML with poor response and prognosis. KMT2Ar-AML has been demonstrated to be sensitive to BCL2 inhibitor venetoclax (VEN), but these patients are unable to benefit from current VEN-based regimen (VEN plus azaci...

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Bibliographic Details
Main Authors: Qing Ling, Yutong Zhou, Yu Qian, Jiejing Qian, Yi Zhang, Jinghan Wang, Yanan Zhu, Yile Zhou, Juying Wei, Chunmei Yang, Jie Sun, Wenjuan Yu, Jie Jin, Xiang Zhang
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Biomarker Research
Subjects:
MENIN inhibitor
Venetoclax
KMT2A rearrangement
Acute myeloid leukemia
HIF-1A-induced HDAC9
Online Access:https://doi.org/10.1186/s40364-023-00547-9

Internet

https://doi.org/10.1186/s40364-023-00547-9

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