Comparison of variants in TPMT and NUDT15 between sequencing and genotyping methods in a multistate pediatric institution

Comparison of variants in TPMT and NUDT15 between sequencing and genotyping methods in a multistate pediatric institution

Abstract The risk of severe adverse events related to thiopurine therapy can be reduced by personalizing dosing based on TPMT and NUDT15 genetic polymorphisms. However, the optimal genetic testing platform has not yet been established. In this study, we report on the TPMT and NUDT15 genotypes and ph...

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Main Authors: Kelsey J. Cook, Victoria Grusauskas, Lucy Gloe, Benjamin Q. Duong, Renee C. Gresh, E. Anders Kolb, Manisha Bansal, Allison S. Bechtel, Ramamoorthy Nagasubramanian, Susan M. Kirwin, Kathryn V. Blake, Nathan D. Seligson
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13539

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https://doi.org/10.1111/cts.13539

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