Metformin promotes angiogenesis and functional recovery in aged mice after spinal cord injury by adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway

Metformin promotes angiogenesis and functional recovery in aged mice after spinal cord injury by adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway

Treatment with metformin can lead to the recovery of pleiotropic biological activities after spinal cord injury. However, its effect on spinal cord injury in aged mice remains unclear. Considering the essential role of angiogenesis during the regeneration process, we hypothesized that metformin acti...

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Bibliographic Details
Main Authors: Jin-Yun Zhao, Xiao-Long Sheng, Cheng-Jun Li, Tian Qin, Run-Dong He, Guo-Yu Dai, Yong Cao, Hong-Bin Lu, Chun-Yue Duan, Jian-Zhong Hu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Neural Regeneration Research
Subjects:
adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway; angiogenesis; aged mice; compound c; metformin; spinal cord injury
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=7;spage=1553;epage=1562;aulast=Zhao

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=7;spage=1553;epage=1562;aulast=Zhao

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