Protein Aggregation Patterns Inform about Breast Cancer Response to Antiestrogens and Reveal the RNA Ligase RTCB as Mediator of Acquired Tamoxifen Resistance

Protein Aggregation Patterns Inform about Breast Cancer Response to Antiestrogens and Reveal the RNA Ligase RTCB as Mediator of Acquired Tamoxifen Resistance

The protein quality control network, including autophagy, the proteasome and the unfolded protein response (UPR), is triggered by stress and is overactive in acquired antiestrogen therapy resistance. We show for the first time that the aggresome load correlates with apoptosis and is increased in ant...

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Bibliographic Details
Main Authors: Inês Direito, Liliana Monteiro, Tânia Melo, Daniela Figueira, João Lobo, Vera Enes, Gabriela Moura, Rui Henrique, Manuel A. S. Santos, Carmen Jerónimo, Francisco Amado, Margarida Fardilha, Luisa A. Helguero
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
breast cancer
estrogen receptors
antiestrogen resistance
protein aggregation
tRNA-splicing ligase RTCB homolog (RTCB)
Online Access:https://www.mdpi.com/2072-6694/13/13/3195

Internet

https://www.mdpi.com/2072-6694/13/13/3195

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