Intratumor heterogeneity of driver mutations and TMB distribution in 30 early-stage LUAD patients with multiple lesions

Intratumor heterogeneity of driver mutations and TMB distribution in 30 early-stage LUAD patients with multiple lesions

BackgroundDifferentiating multiple pulmonary lesions as multiple primary lung cancer (MLC) or intra-pulmonary metastasis (IPM) is critical. Lung cancer also has a high genetic heterogeneity, which influenced the treatment strategy. Genetic information may aid in tracing lineage information on multip...

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Bibliographic Details
Main Authors: Yuan Qiu, Liping Liu, Haihong Yang, Hanzhang Chen, Qiuhua Deng, Dakai Xiao, Yongping Lin, Changbin Zhu, Weiwei Li, Di Shao, Wenxi Jiang, Kui Wu, Jianxing He
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
driver mutation
egfr
tmb
heterogeneity
luad
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.952572/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.952572/full

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