Testing the effect of PAR1 inhibitors on Plasmodium falciparum-induced loss of endothelial cell barrier function [version 3; peer review: 2 approved]
Background: Sequestration and cytoadherence of Plasmodium falciparum-infected erythrocytes (IE) to microvascular endothelium alters endothelial barrier function and plays a role in the pathogenesis of severe malaria. Binding of IE is mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1)...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wellcome
2020-07-01
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| Series: | Wellcome Open Research |
| Online Access: | https://wellcomeopenresearch.org/articles/5-34/v3 |