Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity

Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity

ABSTRACT Gastrointestinal microbes respond to biochemical metabolites that coordinate their behaviors. Here, we demonstrate that bacterial indole functions as a multifactorial mitigator of Klebsiella grimontii and Klebsiella oxytoca pathogenicity. These closely related microbes produce the enterotox...

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Bibliographic Details
Main Authors: Nagender Ledala, Mishika Malik, Karim Rezaul, Sara Paveglio, Anthony Provatas, Aaron Kiel, Melissa Caimano, Yanjiao Zhou, Jonathan Lindgren, Kristyna Krasulova, Peter Illes, Zdeněk Dvořák, Sandhya Kortagere, Sabine Kienesberger, Amar Cosic, Lisa Pöltl, Ellen L. Zechner, Subho Ghosh, Sridhar Mani, Justin D. Radolf, Adam P. Matson
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mBio
Subjects:
Klebsiella oxytoca complex
pregnane X receptor
cytotoxin
indole
intestinal inflammation
Online Access:https://journals.asm.org/doi/10.1128/mbio.03752-21

Internet

https://journals.asm.org/doi/10.1128/mbio.03752-21

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