Lack of Parkinsonian Pathology and Neurodegeneration in Mice After Long-Term Injections of a Proteasome Inhibitor in Olfactory Bulb and Amygdala

Lack of Parkinsonian Pathology and Neurodegeneration in Mice After Long-Term Injections of a Proteasome Inhibitor in Olfactory Bulb and Amygdala

Proteinaceous inclusions, called Lewy bodies (LBs), are used as a pathological hallmark for Parkinson’s disease (PD). Recent studies suggested a prion-like spreading mechanism for α-synucleinopathy where early neuropathological deposits occur, among others, in the olfactory bulb (OB) and amygdala. L...

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Bibliographic Details
Main Authors: Natalia Lopez-Gonzalez del Rey, Tiziano Balzano, Lucia Martin-Rodriguez, Constanza Salinas-Rebolledo, Ines Trigo-Damas, Alejandro Rojas-Fernandez, Lydia Alvarez-Erviti, Javier Blesa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
proteasome inhibition
lactacystin
neuroinflammation
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.698979/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.698979/full

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