Cancer immunotherapy by silencing transcription factor c-Rel using peptide-based nanoparticles

Cancer immunotherapy by silencing transcription factor c-Rel using peptide-based nanoparticles

BackgroundCancer immunotherapy has shown promising results in the clinic, but it faces great challenges such as low response rates and low efficacy in solid tumors. c-Rel, a member of the nuclear factor (NF)-κB family, is a newly described immune checkpoint for myeloid-derived suppressor cells (MDSC...

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Bibliographic Details
Main Authors: Shuyao Lang, Yuxuan Zhu, Zibin Tan, Yu Zhang, Ruijing Liang, Jian Ren, Ping Li, Fan Pan, Lintao Cai, Youhai H. Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
cancer immunotherapy
immune checkpoint
myeloid-derived suppressor cells
c-Rel
NF-κB
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1554496/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1554496/full

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