Atg5 deficiency in macrophages protects against kidney fibrosis via the CCR6-CCL20 axis

Atg5 deficiency in macrophages protects against kidney fibrosis via the CCR6-CCL20 axis

Abstract Background Autophagy is a lysosome-dependent degradation pathway that regulates macrophage activation, differentiation, and polarization. Autophagy related 5 (Atg5) is a key protein involved in phagocytic membrane elongation in autophagic vesicles that forms a complex with Atg12 and Atg16L1...

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Bibliographic Details
Main Authors: Yufeng Zhu, Jiexing Tan, Yuanzhan Wang, Yuhong Gong, Xiaoyong Zhang, Ziguo Yuan, Xinyu Lu, Huifang Tang, Zhiming Zhang, Xiaotao Jiang, Wei Zhu, Li Gong
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cell Communication and Signaling
Subjects:
Autophagy-related 5
Autophagy
Acute kidney injury
Macrophage
Renal fibrosis
Online Access:https://doi.org/10.1186/s12964-024-01600-2

Internet

https://doi.org/10.1186/s12964-024-01600-2

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