4-Octyl itaconate attenuates renal tubular injury in db/db mice by activating Nrf2 and promoting PGC-1α-mediated mitochondrial biogenesis

4-Octyl itaconate attenuates renal tubular injury in db/db mice by activating Nrf2 and promoting PGC-1α-mediated mitochondrial biogenesis

Objectives: The aim of this study was to investigate the mechanism of itaconate’s potential effect in diabetic kidney disease.Methods: Renal immune responsive gene 1 (IRG1) levels were measured in db/db mice and streptozotocin (STZ) + high-fat diet (HFD)-induced diabetic mice. Irg1 knockout mice wer...

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Bibliographic Details
Main Authors: Muqing Shao, Jiayao Chen, Fuwei Zhang, Qian Su, Xiaoqian Lin, Weiwei Wang, Caiyu Chen, Hongmei Ren, Shuo Zheng, Suocheng Hui, Si Qin, Yinxing Ni, Jian Zhong, Jian Yang
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
Diabetic kidney disease
immune responsive gene 1
mitochondrial biogenesis
Nrf2
4-octyl itaconate
renal tubular injury
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2403653

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https://www.tandfonline.com/doi/10.1080/0886022X.2024.2403653

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