Functional epitopes on hepatitis E virions and recombinant capsids are highly conformation-dependent

Functional epitopes on hepatitis E virions and recombinant capsids are highly conformation-dependent

Hepatitis E virus (HEV) is responsible for epidemic and sporadic acute hepatitis cases, especially in developing countries. Hepatitis E has become a vaccine-preventable disease in recent years with the development of a licensed vaccine. Most functional and neutralizing monoclonal antibodies (mAbs) a...

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Bibliographic Details
Main Authors: Bin He, Zhigang Zhang, Xinyuan Zhang, Zimin Tang, Chang Liu, Zizheng Zheng, Shaowei Li, Jun Zhang, Ningshao Xia, Qinjian Zhao
Format: Article
Language:English
Published: Taylor & Francis Group 2020-07-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
conformational epitope
functional assessment
hepatitis e virus
hev p239 vaccine
particulate antigen
neutralizing antibody
serological assay
Online Access:http://dx.doi.org/10.1080/21645515.2019.1703454

Internet

http://dx.doi.org/10.1080/21645515.2019.1703454

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