Preventive efficacy of oral moxidectin at various doses and dosage regimens against macrocyclic lactone-resistant heartworm (Dirofilaria immitis) strains in dogs

Preventive efficacy of oral moxidectin at various doses and dosage regimens against macrocyclic lactone-resistant heartworm (Dirofilaria immitis) strains in dogs

Abstract Background Moxidectin has previously shown limited efficacy (≤ 44.4%) against confirmed macrocyclic lactone (ML)-resistant Dirofilaria immitis strains at 3 µg/kg after single and multiple oral dosages. Three studies were conducted to evaluate higher oral moxidectin doses for efficacy agains...

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Bibliographic Details
Main Authors: Tom L. McTier, Robert H. Six, Aleah Pullins, Sara Chapin, Kristina Kryda, Sean P. Mahabir, Debra J. Woods, Steven J. Maeder
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Parasites & Vectors
Subjects:
Dirofilaria immitis
Heartworm
Canine
Macrocyclic lactone
Resistance
Moxidectin
Online Access:http://link.springer.com/article/10.1186/s13071-019-3685-3

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http://link.springer.com/article/10.1186/s13071-019-3685-3

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