Cyclo(Pro-Tyr) elicits conserved cellular damage in fungi by targeting the [H+]ATPase Pma1 in plasma membrane domains

Cyclo(Pro-Tyr) elicits conserved cellular damage in fungi by targeting the [H+]ATPase Pma1 in plasma membrane domains

Abstract Bioactive metabolites play a crucial role in shaping interactions among diverse organisms. In this study, we identified cyclo(Pro-Tyr), a metabolite produced by Bacillus velezensis, as a potent inhibitor of Botrytis cinerea and Caenorhabditis elegans, two potential cohabitant eukaryotic org...

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Bibliographic Details
Main Authors: D. Vela-Corcia, J. Hierrezuelo, A. I. Pérez-Lorente, P. Stincone, A. K. Pakkir Shah, A. Grélard, Y. Zi-Long, A. de Vicente, A. Pérez García, L. Bai, A. Loquet, D. Petras, D. Romero
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06947-3

Internet

https://doi.org/10.1038/s42003-024-06947-3

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