Intra-Articular injection of acid-sensitive stearoxyl-ketal-dexamethasone microcrystals for long-acting arthritis therapy

Despite advances in treatment of chronic arthritis, there is still a strong need for the development of long-acting formulations that can enable local and sustained drug release at the inflamed tissues. In this work, we fabricated microcrystals of an acid-sensitive stearoxyl-ketal-dexamethasone prod...

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Bibliographic Details
Main Authors: Yang Xu, Ziqi Chen, Zunkai Xu, Yanyan Du, Jianghao Han, Xiaoyong Yuan, Shubiao Zhang, Shutao Guo
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087620307066