Instrumental Heterogeneity in Sex-Specific Two-Sample Mendelian Randomization: Empirical Results From the Relationship Between Anthropometric Traits and Breast/Prostate Cancer

Instrumental Heterogeneity in Sex-Specific Two-Sample Mendelian Randomization: Empirical Results From the Relationship Between Anthropometric Traits and Breast/Prostate Cancer

BackgroundIn two-sample Mendelian randomization (MR) studies, sex instrumental heterogeneity is an important problem needed to address carefully, which however is often overlooked and may lead to misleading causal inference.MethodsWe first employed cross-trait linkage disequilibrium score regression...

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Bibliographic Details
Main Authors: Yixin Gao, Jinhui Zhang, Huashuo Zhao, Fengjun Guan, Ping Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Genetics
Subjects:
two-sample Mendelian randomization
sex-specific and sex-combined instrumental variable
sex heterogeneity
causal effect estimation
summary statistics
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.651332/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.651332/full

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