Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model

Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model

Mycobacterium tuberculosis is the pathogenic bacterium that causes tuberculosis (TB), one of the most lethal infectious diseases in the world. The only vaccine against TB is minimally protective, and multi-drug resistant TB necessitates new therapeutics to treat infection. Developing new therapies r...

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Bibliographic Details
Main Authors: Hayley C. Warsinske, Elsje Pienaar, Jennifer J. Linderman, Joshua T. Mattila, Denise E. Kirschner
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
cells-T cells
cytotoxic
infections-bacterial
transforming growth factor beta
tuberculosis
pulmonary
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01843/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01843/full

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