G-quadruplex is critical to epigenetic activation of the lncRNA HOTAIR in cancer cells

G-quadruplex is critical to epigenetic activation of the lncRNA HOTAIR in cancer cells

Summary: The cancer-promoting lncRNA HOTAIR has multiple isoforms. Which isoform of HOTAIR accounts for its expression and functions in cancer is unknown. Unlike HOTAIR’s canonical intergenic isoform NR_003716 (HOTAIR-C), the novel isoform NR_047517 (HOTAIR-N) forms an overlapping antisense transcri...

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Bibliographic Details
Main Authors: Xiaohan Qu, Zhen Lin, Janarthanan Jayawickramarajah, John S. Alsager, Emily Schmidt, Kenneth P. Nephew, Fang Fang, Shankar Balasubramanian, Bin Shan
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:iScience
Subjects:
Molecular Structure
Epigenetics
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223026366

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http://www.sciencedirect.com/science/article/pii/S2589004223026366

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