SWI/SNF complex gene variations are associated with a higher tumor mutational burden and a better response to immune checkpoint inhibitor treatment: a pan-cancer analysis of next-generation sequencing data corresponding to 4591 cases

SWI/SNF complex gene variations are associated with a higher tumor mutational burden and a better response to immune checkpoint inhibitor treatment: a pan-cancer analysis of next-generation sequencing data corresponding to 4591 cases

Abstract Background Genes related to the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex are frequently mutated across cancers. SWI/SNF-mutant tumors are vulnerable to synthetic lethal inhibitors. However, the landscape of SWI/SNF mutations and their associations with tumor muta...

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Bibliographic Details
Main Authors: Yue Li, Xinhua Yang, Weijie Zhu, Yuxia Xu, Jiangjun Ma, Caiyun He, Fang Wang
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Cancer Cell International
Subjects:
SWI/SNF complex genes
Mutational landscape
Tumor mutational burden
Microsatellite instability
Immune checkpoint inhibitors
Synthetic lethality
Online Access:https://doi.org/10.1186/s12935-022-02757-x

Internet

https://doi.org/10.1186/s12935-022-02757-x

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