Structure guided studies of the interaction between PTP1B and JAK

Structure guided studies of the interaction between PTP1B and JAK

Abstract Protein Tyrosine Phosphatase 1B (PTP1B) is the prototypical protein tyrosine phosphatase and plays an essential role in the regulation of several kinase-driven signalling pathways. PTP1B displays a preference for bisphosphorylated substrates. Here we identify PTP1B as an inhibitor of IL-6 a...

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Main Authors: Rhiannon Morris, Narelle Keating, Cyrus Tan, Hao Chen, Artem Laktyushin, Tamanna Saiyed, Nicholas P. D. Liau, Nicos A. Nicola, Tony Tiganis, Nadia J. Kershaw, Jeffrey J. Babon
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05020-9

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https://doi.org/10.1038/s42003-023-05020-9

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