Probabilistic quotient’s work and pharmacokinetics’ contribution: countering size effect in metabolic time series measurements

Abstract Metabolomic time course analyses of biofluids are highly relevant for clinical diagnostics. However, many sampling methods suffer from unknown sample sizes, commonly known as size effects. This prevents absolute quantification of biomarkers. Recently, several mathematical post acquisition n...

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Bibliographic Details
Main Authors: Mathias Gotsmy, Julia Brunmair, Christoph Büschl, Christopher Gerner, Jürgen Zanghellini
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Bioinformatics
Subjects:
Online Access:https://doi.org/10.1186/s12859-022-04918-1