Stepwise candidate drug screening for myopia control by using zebrafish, mouse, and Golden Syrian Hamster myopia models

Stepwise candidate drug screening for myopia control by using zebrafish, mouse, and Golden Syrian Hamster myopia models

Background: We developed a preclinical protocol for the screening of candidate drugs able to control myopia and prevent its progression. The protocol uses zebrafish, C57BL/6 mice, and golden Syrian hamster models of myopia. Methods: A morpholino (MO) targeting the zebrafish lumican gene (zlum) was i...

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Bibliographic Details
Main Authors: Meng-Yin Lin, I-Tsen Lin, Yu-Ching Wu, I-Jong Wang
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:EBioMedicine
Subjects:
Myopia
Zebrafish
C57BL/6 mouse
Golden Syrian hamster
MMP inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421000566

Internet

http://www.sciencedirect.com/science/article/pii/S2352396421000566

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