Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells

Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells

Selective differentiation of CD4+ T helper (Th) cells into specialized subsets such as Th1 and Th2 cells is a key element of the adaptive immune system driving appropriate immune responses. Besides those canonical Th-cell lineages, hybrid phenotypes such as Th1/2 cells arise in vivo, and their gener...

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Bibliographic Details
Main Authors: Philipp Burt, Michael Peine, Caroline Peine, Zuzanna Borek, Sebastian Serve, Michael Floßdorf, Ahmed N. Hegazy, Thomas Höfer, Max Löhning, Kevin Thurley
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
T helper cell
cell differentiation
time-course transcriptomics
regression analysis
lineage commitment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.928018/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.928018/full

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