Isoniazid resistance-conferring mutations are associated with highly variable phenotypic resistance

Background: High-dose isoniazid is recommended in the 9–12 months short-course regimen for multidrug-resistant tuberculosis with inhA mutation. However, there is insufficient evidence to support the assumption of genotypic-phenotypic concordance. This study aimed to identify the genetic mutations as...

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Bibliographic Details
Main Authors: Senamile Lale Ngema, Navisha Dookie, Rubeshan Perumal, Louansha Nandlal, Nikita Naicker, Marothi Peter Letsoalo, Max O'Donnell, Azraa Khan, Nesri Padayatchi, Kogieleum Naidoo
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405579423000438