Ubiquitin-binding site 1 of pathogenic ataxin-3 regulates its toxicity in Drosophila models of Spinocerebellar Ataxia Type 3

Ubiquitin-binding site 1 of pathogenic ataxin-3 regulates its toxicity in Drosophila models of Spinocerebellar Ataxia Type 3

Spinocerebellar Ataxia Type 3 (SCA3) is a member of the family of polyglutamine (polyQ) diseases that are caused by anomalous CAG triplet repeat expansions in several genes. SCA3 results from abnormal polyQ expansion in the deubiquitinase (DUB), ataxin-3 (Atxn3). To understand the role of the differ...

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Bibliographic Details
Main Authors: Matthew V. Prifti, Kozeta Libohova, Autumn L. Harris, Wei-Ling Tsou, Sokol V. Todi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Neuroscience
Subjects:
ataxia
CAG triplet repeat
Drosophila
misfolding and aggregation
neurodegeneration
polyglutamine (polyQ)
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.1112688/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.1112688/full

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