Paracrine Effects of Renal Proximal Tubular Epithelial Cells on Podocyte Injury under Hypoxic Conditions Are Mediated by Arginase-II and TGF-β1

Paracrine Effects of Renal Proximal Tubular Epithelial Cells on Podocyte Injury under Hypoxic Conditions Are Mediated by Arginase-II and TGF-β1

Hypoxia is an important risk for renal disease. The mitochondrial enzyme arginase-II (Arg-II) is expressed and/or induced by hypoxia in proximal tubular epithelial cells (PTECs) and in podocytes, leading to cellular damage. Because PTECs are vulnerable to hypoxia and located in proximity to podocyte...

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Bibliographic Details
Main Authors: Yiqiong Ma, Duilio Michele Potenza, Guillaume Ajalbert, Andrea Brenna, Cui Zhu, Xiu-Fen Ming, Zhihong Yang
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
arginase
hypoxia
kidney
podocyte
TGF-β1
tubular epithelial cells
Online Access:https://www.mdpi.com/1422-0067/24/4/3587

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https://www.mdpi.com/1422-0067/24/4/3587

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