Agrimol B inhibits colon carcinoma progression by blocking mitochondrial function through the PGC-1α/NRF1/TFAM signaling pathway

Agrimol B inhibits colon carcinoma progression by blocking mitochondrial function through the PGC-1α/NRF1/TFAM signaling pathway

BackgroundThe activation of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) stimulates the transcription of the downstream target proteins, mitochondrial transcription factor A (TFAM) and nuclear respiratory factor 1 (NRF1), which induces mitochondrial biogenesis and promotes co...

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Bibliographic Details
Main Authors: Dongyang Xiang, Wenjuan Yang, Zihan Fang, Jialei Mao, Qiuying Yan, Liu Li, Jiani Tan, Chengtao Yu, Jun Qian, Dongxin Tang, Xiaoting Pan, Haibo Cheng, Dongdong Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
agrimol B
colorectal cancer
PGC-1α
ROS
mitochondrial activity
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1055126/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1055126/full

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