Agrimol B inhibits colon carcinoma progression by blocking mitochondrial function through the PGC-1α/NRF1/TFAM signaling pathway

Agrimol B inhibits colon carcinoma progression by blocking mitochondrial function through the PGC-1α/NRF1/TFAM signaling pathway

BackgroundThe activation of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) stimulates the transcription of the downstream target proteins, mitochondrial transcription factor A (TFAM) and nuclear respiratory factor 1 (NRF1), which induces mitochondrial biogenesis and promotes co...

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Bibliographic Details
Main Authors:	Dongyang Xiang, Wenjuan Yang, Zihan Fang, Jialei Mao, Qiuying Yan, Liu Li, Jiani Tan, Chengtao Yu, Jun Qian, Dongxin Tang, Xiaoting Pan, Haibo Cheng, Dongdong Sun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Series:	Frontiers in Oncology
Subjects:	agrimol B colorectal cancer PGC-1α ROS mitochondrial activity
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.1055126/full

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