Crohn’s disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome

Crohn’s disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome

Abstract Background Crohn’s disease (CD) patients demonstrate distinct intestinal microbial compositions and metabolic characteristics compared to unaffected controls. However, the impact of inflammation and underlying genetic risk on these microbial profiles and their relationship to disease phenot...

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Bibliographic Details
Main Authors: Jonathan P. Jacobs, Maryam Goudarzi, Venu Lagishetty, Dalin Li, Tytus Mak, Maomeng Tong, Paul Ruegger, Talin Haritunians, Carol Landers, Philip Fleshner, Eric Vasiliauskas, Andrew Ippoliti, Gil Melmed, David Shih, Stephan Targan, James Borneman, Albert J. Fornace, Dermot P. B. McGovern, Jonathan Braun
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Genome Medicine
Subjects:
Crohn’s disease
Obesity
Microbiome
Mucosal-luminal interface
Disease behavior
Disease progression
Online Access:https://doi.org/10.1186/s13073-022-01099-7

Internet

https://doi.org/10.1186/s13073-022-01099-7

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