Optogenetic Stimulation of GABAergic Neurons in the Globus Pallidus Produces Hyperkinesia

Optogenetic Stimulation of GABAergic Neurons in the Globus Pallidus Produces Hyperkinesia

The globus pallidus (GP) is emerging as a critical locus of basal ganglia control of motor activity, but the exact role of GABAergic GP neurons remain to be defined. By targeted expression of channelrhodopsin 2 (ChR2) in GABAergic neurons using the VGAT-ChR2-EYFP transgenic mice, we showed that opto...

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Bibliographic Details
Main Authors: Jun Tian, Yaping Yan, Wang Xi, Rui Zhou, Huifang Lou, Shumin Duan, Jiang Fan Chen, Baorong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
optogenetic stimulation
GABAergic neurons
hyperkinesia
movement disorders
globus pallidus
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2018.00185/full

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https://www.frontiersin.org/article/10.3389/fnbeh.2018.00185/full

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