Tracking virus-specific CD4+ T cells during and after acute hepatitis C virus infection.

Tracking virus-specific CD4+ T cells during and after acute hepatitis C virus infection.

CD4+ T cell help is critical in maintaining antiviral immune responses and such help has been shown to be sustained in acute resolving hepatitis C. In contrast, in evolving chronic hepatitis C CD4+ T cell helper responses appear to be absent or short-lived, using functional assays.Here we used a nov...

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Bibliographic Details
Main Authors: Michaela Lucas, Axel Ulsenheimer, Katja Pfafferot, Malte H J Heeg, Silvana Gaudieri, Norbert Grüner, Andri Rauch, J Tilman Gerlach, Maria-Christina Jung, Reinhart Zachoval, Gerd R Pape, Winfried Schraut, Teresa Santantonio, Hans Nitschko, Martin Obermeier, Rodney Phillips, Thomas J Scriba, Nasser Semmo, Cheryl Day, Jonathan N Weber, Sarah Fidler, Robert Thimme, Anita Haberstroh, Thomas F Baumert, Paul Klenerman, Helmut M Diepolder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1920556?pdf=render

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http://europepmc.org/articles/PMC1920556?pdf=render

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