scRNA-seq characterizing the heterogeneity of fibroblasts in breast cancer reveals a novel subtype SFRP4+ CAF that inhibits migration and predicts prognosis

scRNA-seq characterizing the heterogeneity of fibroblasts in breast cancer reveals a novel subtype SFRP4+ CAF that inhibits migration and predicts prognosis

IntroductionCancer-associated fibroblasts (CAFs) are a diverse group of cells that significantly impact the tumor microenvironment and therapeutic responses in breast cancer (BC). Despite their importance, the comprehensive profile of CAFs in BC remains to be fully elucidated.MethodsTo address this...

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Bibliographic Details
Main Authors: Lvwen Ning, Chuntao Quan, Yue Wang, Zhijie Wu, Peixiu Yuan, Ni Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Oncology
Subjects:
breast cancer
cancer-associated fibroblast
SFRP4+ CAF
prognosis
heterogeneity
WNT
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1348299/full

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https://www.frontiersin.org/articles/10.3389/fonc.2024.1348299/full

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