Downregulation of miR-122-5p Activates Glycolysis via PKM2 in Kupffer Cells of Rat and Mouse Models of Non-Alcoholic Steatohepatitis

Downregulation of miR-122-5p Activates Glycolysis via PKM2 in Kupffer Cells of Rat and Mouse Models of Non-Alcoholic Steatohepatitis

Non-alcoholic steatohepatitis (NASH) has pathological characteristics similar to those of alcoholic hepatitis, despite the absence of a drinking history. The greatest threat associated with NASH is its progression to cirrhosis and hepatocellular carcinoma. The pathophysiology of NASH is not fully un...

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Bibliographic Details
Main Authors: Yosuke Inomata, Jae-Won Oh, Kohei Taniguchi, Nobuhiko Sugito, Nao Kawaguchi, Fumitoshi Hirokawa, Sang-Woong Lee, Yukihiro Akao, Shinji Takai, Kwang-Pyo Kim, Kazuhisa Uchiyama
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
NASH
microRNA (miRNA)
miR-122-5p
PKM2
Kupffer cells
macrophages
Online Access:https://www.mdpi.com/1422-0067/23/9/5230

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https://www.mdpi.com/1422-0067/23/9/5230

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