De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling.

De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling.

Malignant carcinomas that recur following therapy are typically de-differentiated and multidrug resistant (MDR). De-differentiated cancer cells acquire MDR by up-regulating reactive oxygen species (ROS)-scavenging enzymes and drug efflux pumps, but how these genes are up-regulated in response to de-...

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Bibliographic Details
Main Authors: Catherine A Del Vecchio, Yuxiong Feng, Ethan S Sokol, Erik J Tillman, Sandhya Sanduja, Ferenc Reinhardt, Piyush B Gupta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-09-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4159113?pdf=render

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http://europepmc.org/articles/PMC4159113?pdf=render

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