Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy

Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy

Abstract In the early stages of diabetic retinopathy (DR), diabetes-related hyperglycemia directly inhibits the AKT signaling pathway by increasing oxidative stress or inhibiting growth factor expression, which leads to retinal cell apoptosis, nerve proliferation and fundus microvascular disease. Ho...

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Bibliographic Details
Main Authors: Jiayuan Li, Kuangqi Chen, Xiang Li, Xuhong Zhang, Liyue Zhang, Qianjie Yang, Yutong Xia, Chen Xie, Xiawei Wang, Jianping Tong, Ye Shen
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01717-2

Internet

https://doi.org/10.1038/s41420-023-01717-2

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