Systematic analysis of Mendelian disease-associated gene variants reveals new classes of cancer-predisposing genes

Systematic analysis of Mendelian disease-associated gene variants reveals new classes of cancer-predisposing genes

Abstract Background Despite the acceleration of somatic driver gene discovery facilitated by recent large-scale tumor sequencing data, the contribution of inherited variants remains largely unexplored, primarily focusing on previously known cancer predisposition genes (CPGs) due to the low statistic...

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Bibliographic Details
Main Authors: Seulki Song, Youngil Koh, Seokhyeon Kim, Sang Mi Lee, Hyun Uk Kim, Jung Min Ko, Se-Hoon Lee, Sung-Soo Yoon, Solip Park
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Genome Medicine
Subjects:
Mendelian disease-associated gene
Cancer predisposition gene
Pathogenic variant
Cancer genomics
Online Access:https://doi.org/10.1186/s13073-023-01252-w

Internet

https://doi.org/10.1186/s13073-023-01252-w

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